Hypersizer Version 5.7.6 is programmed to include one value of Do, and is applicable for both tension and compression.
A work around is to determine the critical loading condition and modify Do as appropriate.
A future HyperSizer revision could include the capability of both tension and compression values of Do and may also include a value of Do dependent on the percentage of 45 deg or 0 deg plies. These Do values would also be component based.